Pharmacokinetics of an injectable long-acting formulation of doxycycline hyclate in dogs
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چکیده
منابع مشابه
Pharmacokinetics of an injectable long-acting formulation of doxycycline hyclate in dogs
Based on its PK/PD ratios, doxycycline hyclate (DOX-h), a time-dependant antibacterial, is ideally expected to achieve both sustained plasma drug concentrations at or slightly above the MIC level for as long as possible between dosing intervals. Pursuing this end, a poloxamer-based matrix was used to produce a long-acting injectable preparation (DOX-h-LA) and its serum concentrations vs. time p...
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A number of ways have been investigated for administration of antibacterial agents in dealing of plaque-initiated periodontal disease. These include prolonged release intrapocket devices which are inserted at diseased sites. Intrapocket drug delivery system was designed which contain Doxycycline Hyclate an antibacterial agent. The formulations were so developed with an aim to reduce the dose of...
متن کاملAn approach to Improve Therapeutic Efficacy of Doxycycline Hyclate in Treatment of Periodontitis
A number of ways have been investigated for administration of antibacterial agents in dealing of plaque-initiated periodontal disease. These include prolonged release intrapocket devices which are inserted at diseased sites. Intrapocket drug delivery system was designed which contain Doxycycline Hyclate an antibacterial agent. The formulations were so developed with an aim to reduce the dose of...
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ژورنال
عنوان ژورنال: Acta Veterinaria Scandinavica
سال: 2012
ISSN: 1751-0147
DOI: 10.1186/1751-0147-54-35